USMLE USMLE - United States Medical Licensing Examination

USMLE USMLE Actual PDF
  • Exam Code: USMLE
  • Exam Name: United States Medical Licensing Examination
  • Updated: Sep 15, 2026
  • Q & A: 400 Questions and Answers
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USMLE Step 2 is open to all medical students and graduates who have successfully passed the USMLE Step 1. The Step 2 exam assesses the candidates' medical knowledge, skills, and understanding of clinical science essential for patient treatment and care, health promotion and disease prevention.

USMLE USMLE Exam Syllabus Topics:

TopicDetails
Topic 1
  • Maladaptive behavioral responses to stress and illness
  • Immunologic and inflammatory disorders
Topic 2
  • Infectious and inflammatory disorders of the eye
  • Adverse effects of drugs on the immune system
Topic 3
  • Adverse effects of drugs on the hematologic and lymphoreticular systems
  • Disorders associated with immunodeficiency
Topic 4
  • Deficiency of phagocytic cells and natural killer cells
  • Adverse effects of drugs on the nervous system
Topic 5
  • Adaptive behavioral responses to stress and illness
  • Biochemistry and molecular biology

Reference: http://www.usmle.org/step-1/#question-formats

USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

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